pentobarbital will reduce the extent or impact of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or result of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or decreased response to tofacitinib may occur when coadministered with strong CYP3